, Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. B Hille. The Journal of general physiology 69 (4), Bertil Hille helped establish the concept of ion channels as membrane proteins forming gated aqueous pores. He showed that Na + and K + channels of axons. Ionic Channels of Excitable Membranes by Bertil Hille (). $ Hardcover. Books by Bertil Hille. Showing 3 Results Books: Advanced Search.

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Nobody promised me any startup money. Fred Dodge was perhaps five years ahead of me.

Function and structure of ion channels

But anyway, that gave an idea that the conductance of the conducting unit, which was still not known to be pore or channel, had to be pretty high, much more consistent with a pore than a carrier. Ions coming from one end could dislodge blockers that had entered the channel from the other end, providing clear evidence for the channel idea.

His work provided the first molecular description of an ion selective channel. No, I have an older brother, who is now a linguist. This was a model for me even before I began experiments. My work was actually started before that. But yes, it was Also we were able to identify charge that, at least in theory, would make the channel nonconductive so that it did not reflux through the open state during recovery from inactivation. So we worked for a long time and finally, I think, two of the major facts that we discovered were that the m system of Hodgkin and Huxley, the idea that there are three independent particles that move during the activation of a sodium channel did not seem to fit well with the turning off kinetics of the sodium channel.


Bertil Hille – Google Scholar Citations

Graduate Work at Rockefeller Hille goes to Rockefeller for graduate work at the suggestion of his gertil as an undergraduate at Yale. So their purpose was to refute the sodium theory, and my purpose was to take their interesting results and interpret it as those ions going through sodium channels, which I did.

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So it was my deficiency as a dissector. Hirofumi Watari University of Hillle. I mean, I sat with these data for a whole year while I just sat and wrestled with the problem of, do I have to take all the water off?

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Armstrong and Hille were thrilled by MacKinnon’s paper. It’s just astounding to see how tall they are and how beautiful. The hillr was beautifully direct: And then in Palade’s lab, I studied holes made in red blood cells by complement, making lysis.

Imagine a nerve in which finely graded input information can be conveyed, by all-or-nothing impulses, all the way from input to output using, let’s bertjl, distinct information channels that extend longitudinally from one end of the nerve to the other.

Debye Cornell Physics Tree. And that I did just by going to the library and reading.

I think it is an extremely rewarding life, much more so than, well, I guess I better not use examples. The familiar picture of individual channels embedded in the cell membrane was brought to us by the magic of long division.


But they actually heard a piece of very good news. He did so by characterizing the gauntlet an ion must run as it traverses the channel’s pore. Mahsa Sadeghi University of Wollongong, Australia.

The permeability of the sodium channel to metal cations in myelinated hlle B Hille The Journal bedtil general physiology 59 6, One wanted a mathematical formalism to explain what we now call gating, and Kacy at the time was trying to understand it in terms of electrodiffusion of ions within the membrane according to the Nernst-Planck ideas and formulation.

Excuse me one second before we get on that. Mullins, in particular—a person who kept being the Devil’s advocate. The longitudinal channels are created by linking transverse channels.

That I’m aware of laughs. He crystallized a potassium channel and determined its entire molecular structure by X-ray diffraction.

Includes new chapters on fast chemical synapses, modulation through G protein-coupled receptors and second messenger systems, molecular cloning, site-directed mutagenesis, and cell biology. So I thought it would be good if you were to begin with a discussion of your life before the Rockefeller—a little bit about your upbringing, your family life, etc.

There was a problem filtering reviews right now. Potassium channels as multi-ion single-file pores. Mainland Monell Chemical Senses Center.